Can Cannabidiol Help Prevent and Treat Gastrointestinal Disorders? Insights from Experts

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Numerous people look for a “cannabis store near me” to buy marijuana, whether it’s for treating a condition or for recreational enjoyment. It’s widely recognized that cannabis products may help alleviate symptoms like anxiety, depression, pain, nausea, and vomiting. Have you thought about its impact on gastrointestinal disorders?

Key Takeaways:

• Cannabinoids in the plant interact with the endocannabinoid system in the GI tract.
• Cannabis and pain medications can aid in managing Irritable Bowel Syndrome symptoms.
• The Healing Co Canada offers Cannabis Sativa for various purposes, primarily known for recreational and medicinal uses.

Gastrointestinal Disorders and Cannabis Plant

The dietary implications of nutraceuticals on gastrointestinal (GI) health are well-established. Certain diets can potentially prevent or alleviate different GI conditions. Researchers have identified and evaluated the food components responsible for these benefits.

Among the plant-derived nutraceuticals that may benefit GI disorders are those derived from cannabis. cannabis refers to products obtained from the cannabis Sativa plant, a fragrant annual flowering herb.

John M. McPartland noted in a scientific review that the Cannabaceae family includes the genera Cannabis, Humulus, and Celtis. The cannabis genus, sativa, has three varieties: Sativa, Indica, and Ruderalis. Depending on the variety, cannabis sativa serves multiple purposes, including fiber production, oil extraction from seeds, and primarily, recreational or medicinal applications.

The Impact of the Plant

Receptors and ligands of the endocannabinoid system are distributed throughout various areas and systems, relevant for regulating GI functions. The presence of cannabinoid receptors allows cannabinoids, including non-psychoactive phytocannabinoids, to modulate GI functions across diverse health and disease states. The ECS plays a role in controlling motility, secretion, epithelial barrier function, and viscerosensitivity.

Irritable Bowel Syndrome (IBS)

IBS has various contributing factors, affecting 10–20% of individuals in developed countries. It presents as functional gastrointestinal disturbances without identifiable organic origins.

The enhancement of the antinociceptive properties of cannabinoids in the presence of inflammation highlights the importance of the ECS in the development of visceral hypersensitivity. This discovery not only clarifies the mechanisms underlying conditions like IBS and other gastrointestinal disorders but also suggests promising therapeutic options for alleviating abdominal and visceral pain.

Cannabinoids alone may not provide significant relief in reducing visceral hypersensitivity among IBS patients. Investigating combinations with other pain-modulating agents, such as opioids, offers an interesting alternative worth exploring.

Inflammatory Bowel Disease (IBD)

IBD, including Crohn’s disease (CD) and ulcerative colitis (UC), is a complex condition of the GI tract. These diseases arise from environmental, genetic, and epigenetic factors.

Cannabidiol shows strong anti-inflammatory effects across various models of intestinal inflammation in animals, as noted in a study published in the Journal of Frontiers in Pharmacology. Both local and systemic administration of CBD demonstrated a dose-dependent improvement in disease indicators:

• Reduction of structural damage
• Mitigation of inflammation-related increases in different cytokines, chemokines, and oxidative stress markers.

A study from the Inflammatory Diseases Journal reported that the primary finding of their research was the challenging tolerability of the botanical extract, with 90% of patients experiencing treatment-related adverse effects compared to 48% receiving the placebo.

There was a trend towards improved quality of life scores and a positive shift in patients’ overall impression of change, according to the per-protocol analysis. The authors speculate that the CBD-rich botanical extract may have therapeutic benefits for patients who can tolerate its effects.

Gastrointestinal Cancer

GI cancers, including colorectal cancer (CRC), are among the most frequently diagnosed conditions in the general population.

Numerous studies have demonstrated CBD’s antiproliferative effects in colorectal cancer models. CBD can protect DNA from oxidative stress, elevate endocannabinoid levels, and inhibit the proliferation of colorectal cancer cells in vitro.

The validation of CBD’s chemopreventive properties was confirmed through studies on in vivo models focusing on AOM-induced colon cancer. A dosage of 1 mg/kg resulted in a significant reduction: ACF decreased by 67%, while the number of tumors and polyps dropped by 66% and 57%, respectively. Increasing the dose to 5 mg/kg was effective primarily in preventing polyp formation.

THC induces apoptosis in colorectal cancer cells by activating the CB1 receptor.

Nausea and Vomiting

Positive effects of CBD occur when combined with THC, as shown in a study published in the British Journal of Clinical Pharmacology. CBD’s anti-nausea and anti-emetic properties may stem from the indirect stimulation of somatodendritic 5-HT1A receptors found in the dorsal raphe nucleus. This receptor activation could lead to a decrease in the release of 5-HT in particular forebrain regions.

Gastroesophageal Reflux Disease (GERD)

Cannabinoids inhibit transient LES relaxations via a CB1-dependent mechanism in both dogs and ferrets, as reported in a study from the Journal of Cannabis and Cannabinoid Research. These findings are significant as transient LES relaxations represent the primary mechanism behind gastroesophageal reflux disease.

Cannabis Sativa for GI Issues

Conclusion

Numerous studies suggest that the benefits of cannabinoids apply not only to the well-known psychoactive compound THC but also to non-psychoactive molecules like CBD and others, which have received comparatively less attention. The cannabis plant affects the GI system by interacting with the ECS to initiate multiple functions that can assist in managing symptoms of specific GI conditions.

Frequently Asked Questions

What can you expect when buying from online cannabis stores?

1. Accessing your cannabis products in Canada from an online store opens up many options featuring both timeless favourites and new products.
2. You can expect additional benefits such as special offers, reliable payment options, and shipping services covering most provinces.
3. Essential resources, such as a blog section or contact page, are available to provide customers with insights or assistance during their shopping experience.
4. As part of the purchase process, you’ll need to verify or confirm your age by presenting identification.
5. Some stores include taxes in their product prices, while others calculate it at checkout.
6. Some dispensaries accept online payments like Interac E-Transfer, while others permit cash on delivery.

What is the measurement unit when buying from a cannabis website?

There are two primary forms of measurement: metric and imperial units. On a cannabis site, you’ll find measurements in grams or ounces, allowing you to locate products like 3.5 grams or 1/8 ounces.

What distinguishes cannabis for medical use from that used recreationally?

Medical cannabis and recreational cannabis originate from the same plant species, but their differing effects and intended applications differentiate them. Medical cannabis acts as a therapeutic aid for specific health conditions, with a higher CBD composition compared to its recreational counterpart.

Are there ready-made joints available in a cannabis store?

Yes. These are sold as pre-rolls. cannabis pre-rolls, or pre-rolled joints and blunts, are convenient options for those who prefer their cannabis ready to use. There’s a growing trend in the popularity of pre-rolled joints infused with cannabis concentrates.

Do cannabis online stores have a physical shop?

Not all online stores have physical locations, meaning you can have your purchases delivered directly to your home rather than needing to pick them up from a physical store after placing an online order.

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